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Kate and Gerry McCann have spent more than £1m trying to find their daughter Madeleine, the couple have said.
Advertising, website costs, legal fees and payments to several detective agencies made up the bulk of the bill.
And Mrs McCann told the Portuguese newspaper Expresso: "We can't set a limit. A child does not have a price. We will pay what we have to."
Madeleine, of Rothley, Leicestershire, disappeared aged three on holiday in the Algarve on 3 May last year.
Mrs McCann said: "It just takes one person to make the one phone call we so hope for. We know she was abducted and believe someone knows or suspects something.
"We want to find her alive. But if she is dead we want to know. There's nothing in the police report that indicates anything bad has happened to her."
The £1m spent so far was described as a "broad figure" by family spokesman Clarence Mitchell, and came from public donations and the proceeds of a £550,000 legal payout from Express newspapers.
The family has received additional financial support from Cheshire-based businessman Brian Kennedy.
There is a further £500,000 remaining in the Find Madeline fund, Mr Mitchell added.
Madeleine photos
In the interview, the couple also said their three-year-old twins, who talk about their sister coming home, had helped them deal with what had happened.
Mrs McCann said: "There are photos of Madeleine all around the house and every day we speak to the twins about her.
"She is an important part of our lives. Sean and Amelie [the twins] still speak about her and involve her in their games."
In the interview, Mrs McCann criticised detective Goncalo Amaral who led the police search for Madeleine and later wrote a book on the case.
"All I will say about this, and because I'm not going to waste my time on Mr Amaral, is that as a professional and as a person his behaviour has been a disgrace."
Mr McCann said they "profoundly regret" that someone saw in their actions the opportunity to take Madeleine, but insisted the couple had not been negligent.
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